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10.1111/j.1582-4934.2008.00334.x http://scihub22266oqcxt.onion/10.1111/j.1582-4934.2008.00334.x C3823362!3823362 !18400049     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18400049 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18400049 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2009 ; 13 (2 ): 365-72 Nephropedia Template TP {{tp|p=18400049 |t=2009. Porosome in astrocytes |pdf=|usr=}}{{18400049 }} gab.com Text Porosome in astrocytes JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18400049 #FOAvip Secretion is a universal cellular process occurring in bakers yeast, to the complex multicellular organisms, to humans beings. Neurotransmission, digestion, immune response or the release of hormones occur as a result of cell secretion. Secretory defects result in numerous diseases and hence a molecular understanding of the process is critical. Cell secretion involves the transport of vesicular products from within cells to the outside. Porosomes are permanent cup-shaped supramolecular structures at the cell plasma membrane, where secretory vesicles transiently dock and transiently fuse to release intravesicular contents to the outside. In the past decade, porosomes have been determined to be the universal secretory machinery in cells, present in the exocrine pancreas, endocrine and neuroendocrine cells, and in neurons. In this study, we report for the first time the presence of porosomes in rat brain astrocytes. Using atomic force microscopy on live astrocytes, cup-shaped porosomes measuring 10-15 nm are observed at the cell plasma membrane. Further studies using electron microscopy confirm the presence of porosomes in astrocytes. Analogous to neuronal porosomes, there is a central plug in the astrocyte porosome complex. Immunoisolation and reconstitution of the astrocyte porosome in lipid membrane, demonstrates a structure similar to what is observed in live cells. These studies demonstrate that in astrocytes, the secretory apparatus at the cell plasma membrane is similar to what is found in neurons. Twit Text FOAVip Porosome in astrocytes ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=18400049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18400049 #FOAvip English Wikipedia <ref>{{Cite pmid|18400049 }}</ref> Porosome in astrocytes #MMPMID18400049 Lee JS ; Cho WJ ; Jeftinija K ; Jeftinija S ; Jena BP J Cell Mol Med 2009[Feb]; 13 (2 ): 365-72 PMID18400049 show ga Secretion is a universal cellular process occurring in bakers yeast, to the complex multicellular organisms, to humans beings. Neurotransmission, digestion, immune response or the release of hormones occur as a result of cell secretion. Secretory defects result in numerous diseases and hence a molecular understanding of the process is critical. Cell secretion involves the transport of vesicular products from within cells to the outside. Porosomes are permanent cup-shaped supramolecular structures at the cell plasma membrane, where secretory vesicles transiently dock and transiently fuse to release intravesicular contents to the outside. In the past decade, porosomes have been determined to be the universal secretory machinery in cells, present in the exocrine pancreas, endocrine and neuroendocrine cells, and in neurons. In this study, we report for the first time the presence of porosomes in rat brain astrocytes. Using atomic force microscopy on live astrocytes, cup-shaped porosomes measuring 10-15 nm are observed at the cell plasma membrane. Further studies using electron microscopy confirm the presence of porosomes in astrocytes. Analogous to neuronal porosomes, there is a central plug in the astrocyte porosome complex. Immunoisolation and reconstitution of the astrocyte porosome in lipid membrane, demonstrates a structure similar to what is observed in live cells. These studies demonstrate that in astrocytes, the secretory apparatus at the cell plasma membrane is similar to what is found in neurons. |*Astrocytes/cytology/metabolism [MESH] |*Cell Membrane/metabolism/ultrastructure [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Exocytosis/*physiology [MESH] |Humans [MESH] |Microscopy, Atomic Force [MESH] |Neurons/cytology/metabolism [MESH] |Rats [MESH] |Secretory Vesicles/metabolism [MESH] |Synaptosomal-Associated Protein 25/metabolism [MESH]Porosome in astrocytes (epmc).pdf DeepDyve Pubget Overpricing