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2015 ; 1851
(6
): 746-58
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Polyphosphoinositide binding domains: Key to inositol lipid biology
#MMPMID25732852
Hammond GR
; Balla T
Biochim Biophys Acta
2015[Jun]; 1851
(6
): 746-58
PMID25732852
show ga
Polyphosphoinositides (PPIn) are an important family of phospholipids located on
the cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are
critical for the regulation of many aspects of membrane homeostasis and
signaling, with notable relevance to human physiology and disease. This
regulation is achieved through the selective interaction of these lipids with
hundreds of cellular proteins, and thus the capability to study these localized
interactions is crucial to understanding their functions. In this review, we
discuss current knowledge of the principle types of PPIn-protein interactions,
focusing on specific lipid-binding domains. We then discuss how these domains
have been re-tasked by biologists as molecular probes for these lipids in living
cells. Finally, we describe how the knowledge gained with these probes, when
combined with other techniques, has led to the current view of the lipids'
localization and function in eukaryotes, focusing mainly on animal cells. This
article is part of a Special Issue entitled Phosphoinositides.
|*Biosensing Techniques
[MESH]
|Adaptor Proteins, Signal Transducing/chemistry/genetics/metabolism
[MESH]