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2016 ; 2016
(ä): 4071735
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Polycystic Ovary Syndrome May Be an Autoimmune Disorder
#MMPMID27274883
Mobeen H
; Afzal N
; Kashif M
Scientifica (Cairo)
2016[]; 2016
(ä): 4071735
PMID27274883
show ga
Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder
affecting females. It is a common cause of menstrual irregularities and
infertility during reproductive age. Genetic and hormonal factors play crucial
role in the pathogenesis of PCOS. Low level of progesterone in PCOS causes
overstimulation of immune system that produces more estrogen which leads to
various autoantibodies. Different autoantibodies have been documented in PCOS,
for example, anti-nuclear (ANA), anti-thyroid, anti-spermatic, anti-SM,
anti-histone, anti-carbonic anhydrase, anti-ovarian, and anti-islet cell
antibodies. There is an association between PCOS and autoimmune diseases such as
ANA and anti-TPO that have been documented in systemic lupus erythematosus and
Hashimoto thyroiditis, respectively, and it is suspected that there are
autoantibodies that might affect the long term clinical management of these
patients. Therefore fluctuating levels of autoantibodies in different PCOS
patients give us the way to open new chapter for future research on molecular
level. This may lead to discovery of better treatment options for PCOS in near
future.