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10.1002/wdev.244 http://scihub22266oqcxt.onion/10.1002/wdev.244 C5518792!5518792 !27581385     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27581385 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Wiley+Interdiscip+Rev+Dev+Biol 2016 ; 5 (6 ): 659-688 Nephropedia Template TP {{tp|p=27581385 |t=2016. Polycomb and trithorax opposition in development and disease |pdf=|usr=}}{{27581385 }} gab.com Text Polycomb and trithorax opposition in development and disease JO: Wiley Interdiscip Rev Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27581385 #FOAvip Early discoveries in chromatin biology and epigenetics heralded new insights into organismal development. From these studies, two mediators of cellular differentiation were discovered: the Polycomb group (PcG) of transcriptional repressors, and the trithorax group (trxG) of transcriptional activators. These protein families, while opposed in function, work together to coordinate the appropriate cellular developmental programs that allow for both embryonic stem cell self-renewal and differentiation. Recently, both the PcG and trxG chromatin modulators have been observed to be deregulated in a wide spectrum diseases including developmental disorders and cancer. To understand the impact of these findings we outline the past, present, and future. WIREs Dev Biol 2016, 5:659-688. doi: 10.1002/wdev.244 For further resources related to this article, please visit the WIREs website. Twit Text FOAVip Polycomb and trithorax opposition in development and disease ????Wiley Interdiscip Rev Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27581385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27581385 #FOAvip English Wikipedia <ref>{{Cite pmid|27581385 }}</ref> Polycomb and trithorax opposition in development and disease #MMPMID27581385 Poynter ST ; Kadoch C Wiley Interdiscip Rev Dev Biol 2016[Nov]; 5 (6 ): 659-688 PMID27581385 show ga Early discoveries in chromatin biology and epigenetics heralded new insights into organismal development. From these studies, two mediators of cellular differentiation were discovered: the Polycomb group (PcG) of transcriptional repressors, and the trithorax group (trxG) of transcriptional activators. These protein families, while opposed in function, work together to coordinate the appropriate cellular developmental programs that allow for both embryonic stem cell self-renewal and differentiation. Recently, both the PcG and trxG chromatin modulators have been observed to be deregulated in a wide spectrum diseases including developmental disorders and cancer. To understand the impact of these findings we outline the past, present, and future. WIREs Dev Biol 2016, 5:659-688. doi: 10.1002/wdev.244 For further resources related to this article, please visit the WIREs website. |*Developmental Biology [MESH] |*Disease [MESH] |Animals [MESH] |Histone-Lysine N-Methyltransferase/*metabolism [MESH] |Humans [MESH] |Myeloid-Lymphoid Leukemia Protein/*metabolism [MESH]Polycomb and trithorax opposition in development and disease (epmc).pdf DeepDyve Pubget Overpricing