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2016 ; 291
(29
): 14896-903
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Polyamines in Eukaryotes, Bacteria, and Archaea
#MMPMID27268252
Michael AJ
J Biol Chem
2016[Jul]; 291
(29
): 14896-903
PMID27268252
show ga
Polyamines are primordial polycations found in most cells and perform different
functions in different organisms. Although polyamines are mainly known for their
essential roles in cell growth and proliferation, their functions range from a
critical role in cellular translation in eukaryotes and archaea, to bacterial
biofilm formation and specialized roles in natural product biosynthesis. At first
glance, the diversity of polyamine structures in different organisms appears
chaotic; however, biosynthetic flexibility and evolutionary and ecological
processes largely explain this heterogeneity. In this review, I discuss the
biosynthetic, evolutionary, and physiological processes that constrain or expand
polyamine structural and functional diversity.