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2014 ; 13
(18
): 2944-51
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Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis
#MMPMID25486481
Li M
; Bian C
; Yu X
Cell Cycle
2014[]; 13
(18
): 2944-51
PMID25486481
show ga
Poly(ADP-ribosyl)ation is an unique posttranslational modification and required
for spindle assembly and function during mitosis. However, the molecular
mechanism of poly(ADP-ribose) (PAR) in mitosis remains elusive. Here, we show the
evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor
in mitosis. The BRCT domain of ECT2 directly binds to PAR both in vitro and in
vivo. We further found that ?-tubulin is PARylated during mitosis. PARylation of
?-tubulin is recognized by ECT2 and recruits ECT2 to mitotic spindle for
completing mitosis. Taken together, our study reveals a novel mechanism by which
PAR regulates mitosis.
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