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10.1083/jcb.201506108 http://scihub22266oqcxt.onion/10.1083/jcb.201506108 C4602047!4602047 !26459595     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26459595 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Cell+Biol 2015 ; 211 (1 ): 19-26 Nephropedia Template TP {{tp|p=26459595 |t=2015. Polarity establishment requires localized activation of Cdc42 |pdf=|usr=}}{{26459595 }} gab.com Text Polarity establishment requires localized activation of Cdc42 JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26459595 #FOAvip Establishment of cell polarity in animal and fungal cells involves localization of the conserved Rho-family guanosine triphosphatase, Cdc42, to the cortical region destined to become the "front" of the cell. The high local concentration of active Cdc42 promotes cytoskeletal polarization through various effectors. Cdc42 accumulation at the front is thought to involve positive feedback, and studies in the budding yeast Saccharomyces cerevisiae have suggested distinct positive feedback mechanisms. One class of mechanisms involves localized activation of Cdc42 at the front, whereas another class involves localized delivery of Cdc42 to the front. Here we show that Cdc42 activation must be localized for successful polarity establishment, supporting local activation rather than local delivery as the dominant mechanism in this system. Twit Text FOAVip Polarity establishment requires localized activation of Cdc42 ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26459595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26459595 #FOAvip English Wikipedia <ref>{{Cite pmid|26459595 }}</ref> Polarity establishment requires localized activation of Cdc42 #MMPMID26459595 Woods B ; Kuo CC ; Wu CF ; Zyla TR ; Lew DJ J Cell Biol 2015[Oct]; 211 (1 ): 19-26 PMID26459595 show ga Establishment of cell polarity in animal and fungal cells involves localization of the conserved Rho-family guanosine triphosphatase, Cdc42, to the cortical region destined to become the "front" of the cell. The high local concentration of active Cdc42 promotes cytoskeletal polarization through various effectors. Cdc42 accumulation at the front is thought to involve positive feedback, and studies in the budding yeast Saccharomyces cerevisiae have suggested distinct positive feedback mechanisms. One class of mechanisms involves localized activation of Cdc42 at the front, whereas another class involves localized delivery of Cdc42 to the front. Here we show that Cdc42 activation must be localized for successful polarity establishment, supporting local activation rather than local delivery as the dominant mechanism in this system. |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Cell Cycle Proteins/metabolism [MESH] |Cell Polarity [MESH] |Enzyme Activation [MESH] |Guanine Nucleotide Exchange Factors/metabolism [MESH] |Protein Transport [MESH] |Saccharomyces cerevisiae Proteins/metabolism [MESH] |Saccharomyces cerevisiae/cytology/*enzymology [MESH]Polarity establishment requires localized activation of Cdc42 (epmc).pdf DeepDyve Pubget Overpricing