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10.1242/jcs.141226 http://scihub22266oqcxt.onion/10.1242/jcs.141226 C4054684!4054684 !24424029     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24424029 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Cell+Sci 2014 ; 127 (Pt 5 ): 1052-1064 Nephropedia Template TP {{tp|p=24424029 |t=2014. Podosomes of dendritic cells facilitate antigen sampling |pdf=|usr=}}{{24424029 }} gab.com Text Podosomes of dendritic cells facilitate antigen sampling JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24424029 #FOAvip Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we show that podosomes of human dendritic cells locate to spots of low physical resistance in the substrate (soft spots) where they can evolve into protrusive structures. Pathogen recognition receptors locate to these protrusive structures where they can trigger localized antigen uptake, processing and presentation to activate T-cells. Our data demonstrate a novel role in antigen sampling for the podosomes of dendritic cells. Twit Text FOAVip Podosomes of dendritic cells facilitate antigen sampling ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24424029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24424029 #FOAvip English Wikipedia <ref>{{Cite pmid|24424029 }}</ref> Podosomes of dendritic cells facilitate antigen sampling #MMPMID24424029 Baranov M ; Ter Beest M ; Reinieren-Beeren I ; Cambi A ; Figdor CG ; van den Bogaart G J Cell Sci 2014[Mar]; 127 (Pt 5 ): 1052-1064 PMID24424029 show ga Dendritic cells sample the environment for antigens and play an important role in establishing the link between innate and acquired immunity. Dendritic cells contain mechanosensitive adhesive structures called podosomes that consist of an actin-rich core surrounded by integrins, adaptor proteins and actin network filaments. They facilitate cell migration via localized degradation of extracellular matrix. Here, we show that podosomes of human dendritic cells locate to spots of low physical resistance in the substrate (soft spots) where they can evolve into protrusive structures. Pathogen recognition receptors locate to these protrusive structures where they can trigger localized antigen uptake, processing and presentation to activate T-cells. Our data demonstrate a novel role in antigen sampling for the podosomes of dendritic cells. |*Antigen Presentation [MESH] |Cell Surface Extensions/*metabolism [MESH] |Cells, Cultured [MESH] |Dendritic Cells/immunology/*metabolism/ultrastructure [MESH] |Endocytosis [MESH] |Humans [MESH] |Matrix Metalloproteinase 14/metabolism [MESH]Podosomes of dendritic cells facilitate antigen sampling (epmc).pdf DeepDyve Pubget Overpricing