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2014 ; 11 Suppl 4
(Suppl 4
): S189-92
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Pneumonia Treatment and diagnosis
#MMPMID25148424
Mattila JT
; Fine MJ
; Limper AH
; Murray PR
; Chen BB
; Lin PL
Ann Am Thorac Soc
2014[Aug]; 11 Suppl 4
(Suppl 4
): S189-92
PMID25148424
show ga
Pneumonia remains a leading cause of morbidity and mortality despite advances in
treatment and therapy. The "Pneumonia: Treatment and Diagnosis" session of the
Pittsburgh International Lung Conference examined topics related to improving
care of patients with pneumonia. These topics included the process and quality of
care for community-acquired pneumonia (CAP), diagnosis and treatment of emerging
fungal pathogens, an overview of the strengths and weaknesses of different
diagnostic modalities, and an example of how basic science is exploring
immunomodulatory strategies for pneumonia treatment. Systematic health care
provider and institutional improvements can decrease mortality rates in CAP,
particularly in patients with increasingly complex comorbidities. Aspects of
current guidelines for the diagnosis and treatment of fungal pneumonia were
reviewed through a series of case presentations. Proper treatment of pneumonia
hinges on correct pathogen identification but is complicated by the variety of
diagnostic assays with variable specificity, sensitivity, and interpretation. In
addressing this topic, Dr. Patrick Murray, Ph.D., discussed a range of diagnostic
tests for a variety of pathogens and guidelines for their use. In addition to the
current state of CAP treatment, Bill (Beibei) Chen, M.D., Ph.D., presented a new
potential therapeutic agent called forsythin, an immunomodulatory compound
derived from a plant used in traditional Chinese medicine. These topics, ranging
from institution-sized policy to interactions at the molecular scale, paint a
broad perspective of the efforts against pneumonia.
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