Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27088424
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Am+Thorac+Soc
2016 ; 13
(6
): 933-44
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pneumococcal Vaccination Strategies An Update and Perspective
#MMPMID27088424
Berical AC
; Harris D
; Dela Cruz CS
; Possick JD
Ann Am Thorac Soc
2016[Jun]; 13
(6
): 933-44
PMID27088424
show ga
Streptococcus pneumoniae is an important global pathogen that causes a wide range
of clinical disease in children and adults. Pneumococcal pneumonia is by far the
common presentation of noninvasive and invasive pneumococcal disease and affects
the young, the elderly, and the immunocompromised disproportionately. Patients
with chronic pulmonary diseases are also at higher risk for pneumococcal
infections. Substantial progress over the century has been made in the
understanding of pneumococcal immunobiology and the prevention of invasive
pneumococcal disease through vaccination. Currently, two pneumococcal vaccines
are available for individuals at risk of pneumococcal disease: the 23-valent
pneumococcal polysaccharide vaccine (PPV23) and the 13-valent pneumococcal
protein-conjugate vaccine (PCV13). The goal of pneumococcal vaccination is to
stimulate effective antipneumococcal antibody and mucosal immunity response and
immunological memory. Vaccination of infants and young children with pneumococcal
conjugate vaccine has led to significant decrease in nasal carriage rates and
pneumococcal disease in all age groups. Recent pneumococcal vaccine indication
and schedule recommendations on the basis of age and risk factors are outlined in
this Focused Review. As new pneumococcal vaccine recommendations are being
followed, continued efforts are needed to address the vaccine efficacy in the
waning immunity of the ever-aging population, the implementation of vaccines
using two different vaccines under very specific schedules and their real world
clinical and cost effectiveness, and the development of next generation
pneumococcal vaccines.
|Cost-Benefit Analysis
[MESH]
|Humans
[MESH]
|Immunity, Herd
[MESH]
|Immunization Schedule
[MESH]
|Pneumococcal Vaccines/*therapeutic use
[MESH]
|Pneumonia, Pneumococcal/epidemiology/*prevention & control
[MESH]