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2017 ; 22
(9
): 1241-1249
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Pluripotent stem cells in neuropsychiatric disorders
#MMPMID28322279
Soliman MA
; Aboharb F
; Zeltner N
; Studer L
Mol Psychiatry
2017[Sep]; 22
(9
): 1241-1249
PMID28322279
show ga
Neuropsychiatric disorders place an enormous medical burden on patients across
all social and economic ranks. The current understanding of the molecular and
cellular causes of neuropsychiatric disease remains limited, which leads to a
lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology
offers a novel platform for modeling the genetic contribution to mental disorders
and yields access to patient-specific cells for drug discovery and personalized
medicine. Here, we review recent progress in using iPSC technology to model and
potentially treat neuropsychiatric disorders by focusing on the most prevalent
conditions in psychiatry, including depression, anxiety disorders, bipolar
disorder and schizophrenia.