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10.1016/j.jaci.2015.02.005 http://scihub22266oqcxt.onion/10.1016/j.jaci.2015.02.005 C4559084!4559084 !26051947     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26051947 &cmd=llinks): Failed to open stream: HTTP request failed! 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Platelets in patients with aspirin-exacerbated respiratory disease |pdf=|usr=}}{{26051947 }} gab.com Text Platelets in patients with aspirin-exacerbated respiratory disease JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051947 #FOAvip Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized clinically by the triad of asthma, nasal polyposis, and pathognomonic respiratory reactions after ingestion of aspirin. It is a distinct syndrome associated with eosinophilic infiltration of respiratory tissues and excessive production of cysteinyl leukotrienes. Despite the consistent clinical phenotype of the respiratory disease, the underlying pathogenesis of the disease remains unclear. In addition to their role in hemostasis, platelets have the capacity to influence the activation state and function of other immune cells during inflammation and to facilitate granulocyte recruitment into the tissues. Platelets also possess a repertoire of potent preformed mediators of inflammation that are released on activation and are a rich source of newly synthesized lipid mediators that alter vascular permeability and smooth muscle tone. Accordingly, platelet activity has been linked to diverse inflammatory diseases, including asthma. Both human and animal studies strongly suggest that platelet activity is uniquely associated with the pathophysiology of AERD. This article summarizes the evidence supporting an effector role for platelets in asthmatic patients in general and in patients with AERD in particular and considers the potential therapeutic implications. Twit Text FOAVip Platelets in patients with aspirin-exacerbated respiratory disease ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26051947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26051947 #FOAvip English Wikipedia <ref>{{Cite pmid|26051947 }}</ref> Platelets in patients with aspirin-exacerbated respiratory disease #MMPMID26051947 Laidlaw TM ; Boyce JA J Allergy Clin Immunol 2015[Jun]; 135 (6 ): 1407-14; quiz 1415 PMID26051947 show ga Aspirin-exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized clinically by the triad of asthma, nasal polyposis, and pathognomonic respiratory reactions after ingestion of aspirin. It is a distinct syndrome associated with eosinophilic infiltration of respiratory tissues and excessive production of cysteinyl leukotrienes. Despite the consistent clinical phenotype of the respiratory disease, the underlying pathogenesis of the disease remains unclear. In addition to their role in hemostasis, platelets have the capacity to influence the activation state and function of other immune cells during inflammation and to facilitate granulocyte recruitment into the tissues. Platelets also possess a repertoire of potent preformed mediators of inflammation that are released on activation and are a rich source of newly synthesized lipid mediators that alter vascular permeability and smooth muscle tone. Accordingly, platelet activity has been linked to diverse inflammatory diseases, including asthma. Both human and animal studies strongly suggest that platelet activity is uniquely associated with the pathophysiology of AERD. This article summarizes the evidence supporting an effector role for platelets in asthmatic patients in general and in patients with AERD in particular and considers the potential therapeutic implications. |Animals [MESH] |Aspirin/immunology [MESH] |Asthma, Aspirin-Induced/*drug therapy/immunology/pathology [MESH] |Blood Platelets/*drug effects/immunology/pathology [MESH] |Bridged Bicyclo Compounds, Heterocyclic/*therapeutic use [MESH] |Cell Movement [MESH] |Clinical Trials as Topic [MESH] |Eosinophils/*drug effects/immunology/pathology [MESH] |Gene Expression [MESH] |Humans [MESH] |Leukotrienes/biosynthesis [MESH] |Oxazoles/*therapeutic use [MESH] |Piperazines/*therapeutic use [MESH] |Platelet Activating Factor/genetics/immunology [MESH] |Platelet Activation [MESH] |Prasugrel Hydrochloride [MESH] |Receptors, Leukotriene/genetics/immunology [MESH] |Thiophenes/*therapeutic use [MESH]Platelets in patients with aspirin-exacerbated respiratory disease (epmc).pdf DeepDyve Pubget Overpricing