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Platelet secretion in inflammatory and infectious diseases
#MMPMID27848259
Manne BK
; Xiang SC
; Rondina MT
Platelets
2017[Mar]; 28
(2
): 155-164
PMID27848259
show ga
Platelets are small, anucleate circulating cells that possess a dynamic
repertoire of functions spanning the hemostatic, inflammatory, and immune
continuum. Once thought to be merely cell fragments with responses limited
primarily to acute hemostasis and vascular wall repair, platelets are now
increasingly recognized as key sentinels and effector cells regulating host
responses to many inflammatory and infectious cues. Platelet granules, including
?-granules and dense-granules, store hundreds of factors and secrete these
mediators in response to activating signals. The cargo packaged and stored within
platelet granules orchestrates communication between platelets and other
circulating cells, augments host defense mechanisms to invading pathogens and
tumor cells, and - in some settings - drives dysregulated and injurious
responses. This focused review will highlight several of the established and
emerging mechanisms and roles of platelet secretion in inflammatory and
infectious diseases.
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