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2015 ; 29
(4
): 215-9
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Platelet MicroRNAs: An Overview
#MMPMID26341586
Dahiya N
; Sarachana T
; Vu L
; Becker KG
; Wood WH 3rd
; Zhang Y
; Atreya CD
Transfus Med Rev
2015[Oct]; 29
(4
): 215-9
PMID26341586
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MicroRNAs (miRNAs) are short ~22-nucleotide noncoding RNA that have been found to
influence the expression of many genes and cellular processes by either
repressing translation or degrading messenger RNA transcripts. Platelet miRNA
expression has been shown to be perturbed during ex vivo storage of platelets and
in platelet-associated disorders. Although bioinformatics-based miRNA target
predictions have been established, direct experimental validation of the role of
miRNAs in platelet biology has been rather slow. Target prediction studies are,
nonetheless, valuable in directing the design of appropriate experiments to test
specific miRNA:messenger RNA interactions relevant to the underlying mechanisms
of platelet function in general and in disease as well as in ex vivo
storage-associated "storage lesions," a collective term used to include
physiologic, biochemical, and morphologic changes that occur in stored platelets.
This brief review will focus on emerging human platelet miRNA studies to
emphasize their potential role relevant to transfusion medicine field in terms of
regulating platelet signaling pathways, markers of platelet associated disorders,
and remote impactors of gene expression (intercellular biomodulators) as well as
potential platelet quality markers of storage and pathogen reduction treatments.
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