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2014 ; 43
(11
): 3835-53
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Plasmonic nanomaterials for biodiagnostics
#MMPMID24323079
Howes PD
; Rana S
; Stevens MM
Chem Soc Rev
2014[Jun]; 43
(11
): 3835-53
PMID24323079
show ga
The application of nanomaterials to detect disease biomarkers is giving rise to
ultrasensitive assays, with scientists exploiting the many advantageous physical
and chemical properties of nanomaterials. The fundamental basis of such work is
to link unique phenomena that arise at the nanoscale to the presence of a
specific analyte biomolecule, and to modulate the intensity of such phenomena in
a ratiometric fashion, in direct proportion with analyte concentration. Precise
engineering of nanomaterial surfaces is of utmost importance here, as the
interface between the material and the biological environment is where the key
interactions occur. In this tutorial review, we discuss the use of plasmonic
nanomaterials in the development of biodiagnostic tools for the detection of a
large variety of biomolecular analytes, and how their plasmonic properties give
rise to tunable optical characteristics and surface enhanced Raman signals. We
put particular focus on studies that have explored the efficacy of the systems
using physiological samples in an effort to highlight the clinical potential of
such assays.
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