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2014 ; 9
(4
): 781-799
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Plasmon-Enhanced Fluorescence Biosensors: a Review
#MMPMID27330521
Bauch M
; Toma K
; Toma M
; Zhang Q
; Dostalek J
Plasmonics
2014[]; 9
(4
): 781-799
PMID27330521
show ga
Surfaces of metallic films and metallic nanoparticles can strongly confine
electromagnetic field through its coupling to propagating or localized surface
plasmons. This interaction is associated with large enhancement of the field
intensity and local optical density of states which provides means to increase
excitation rate, raise quantum yield, and control far field angular distribution
of fluorescence light emitted by organic dyes and quantum dots. Such emitters are
commonly used as labels in assays for detection of chemical and biological
species. Their interaction with surface plasmons allows amplifying fluorescence
signal (brightness) that accompanies molecular binding events by several orders
of magnitude. In conjunction with interfacial architectures for the specific
capture of target analyte on a metallic surface, plasmon-enhanced fluorescence
(PEF) that is also referred to as metal-enhanced fluorescence (MEF) represents an
attractive method for shortening detection times and increasing sensitivity of
various fluorescence-based analytical technologies. This review provides an
introduction to fundamentals of PEF, illustrates current developments in design
of metallic nanostructures for efficient fluorescence signal amplification that
utilizes propagating and localized surface plasmons, and summarizes current
implementations to biosensors for detection of trace amounts of biomarkers,
toxins, and pathogens that are relevant to medical diagnostics and food control.
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