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2016 ; 11
(5
): e0156165
Nephropedia Template TP
Ohashi N
; Isobe S
; Ishigaki S
; Suzuki T
; Iwakura T
; Ono M
; Fujikura T
; Tsuji T
; Otsuka A
; Ishii Y
; Furuse H
; Kato A
; Ozono S
; Yasuda H
PLoS One
2016[]; 11
(5
): e0156165
PMID27228084
show ga
BACKGROUND: (Pro)renin receptor [(P)RR], a specific receptor for renin and
prorenin, was identified as a member of the renin-angiotensin system (RAS). (P)RR
is cleaved by furin, and soluble (P)RR [s(P)RR] is secreted into the
extracellular space. Previous reports have indicated that plasma s(P)RR levels
show a significant positive relationship with urinary protein levels, which
represent renal damage. However, it is not fully known whether plasma s(P)RR
reflects renal damage. METHODS: We recruited 25 patients who were admitted to our
hospital to undergo heminephrectomy. Plasma s(P)RR levels were examined from
blood samples drawn before nephrectomy. The extent of renal damage was evaluated
by the levels of tubulointerstitial fibrosis. Immunohistochemical analysis of
intrarenal (P)RR and cell surface markers (cluster of differentiation [CD]3,
CD19, and CD68) was performed on samples taken from the removed kidney. Moreover,
double staining of (P)RR and cell surface markers was also performed. RESULTS:
There were significant positive relationships between plasma s(P)RR and
tubulointerstitial fibrosis in all the patients and those not receiving RAS
blocker therapy. Significant positive relationships were found between plasma
s(P)RR levels and the extent of tubulointerstitial fibrosis after adjustment for
age, sex, body weight, blood pressure, and plasma angiotensin II, in all the
patients and those not receiving RAS blockers. Moreover, (P)RR expression was
elevated in infiltrated mononuclear cells but not connecting tubules or
collecting ducts and vessels. Infiltrated cells positive for (P)RR consisted of
CD3 and CD68 but not CD19. CONCLUSIONS: These data suggest that plasma s(P)RR
levels may reflect (P)RR expression levels in infiltrated mononuclear cells,
which can be a surrogate marker of renal damage.
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