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2016 ; 11
(3
): e0150440
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Plasma Glutamine Concentrations in Liver Failure
#MMPMID26938452
Helling G
; Wahlin S
; Smedberg M
; Pettersson L
; Tjäder I
; Norberg Å
; Rooyackers O
; Wernerman J
PLoS One
2016[]; 11
(3
): e0150440
PMID26938452
show ga
BACKGROUND: Higher than normal plasma glutamine concentration at admission to an
intensive care unit is associated with an unfavorable outcome. Very high plasma
glutamine levels are sometimes seen in both acute and chronic liver failure. We
aimed to systematically explore the relation between different types of liver
failure and plasma glutamine concentrations. METHODS: Four different groups of
patients were studies; chronic liver failure (n = 40), acute on chronic liver
failure (n = 20), acute fulminant liver failure (n = 20), and post-hepatectomy
liver failure (n = 20). Child-Pugh and Model for End-stage Liver Disease (MELD)
scores were assessed as indices of liver function. All groups except the chronic
liver failure group were followed longitudinally during hospitalisation. Outcomes
were recorded up to 48 months after study inclusion. RESULTS: All groups had
individuals with very high plasma glutamine concentrations. In the total group of
patients (n = 100), severity of liver failure correlated significantly with
plasma glutamine concentration, but the correlation was not strong. CONCLUSION:
Liver failure, regardless of severity and course of illness, may be associated
with a high plasma glutamine concentration. Further studies are needed to
understand whether high glutamine levels should be regarded as a biomarker or as
a contributor to symptomatology in liver failure.
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