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2015 ; 3
(3
): 620-37
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Plant Viruses as Nanoparticle-Based Vaccines and Adjuvants
#MMPMID26350598
Lebel MÈ
; Chartrand K
; Leclerc D
; Lamarre A
Vaccines (Basel)
2015[Aug]; 3
(3
): 620-37
PMID26350598
show ga
Vaccines are considered one of the greatest medical achievements in the battle
against infectious diseases. However, the intractability of various diseases such
as hepatitis C, HIV/AIDS, malaria, tuberculosis, and cancer poses persistent
hurdles given that traditional vaccine-development methods have proven to be
ineffective; as such, these challenges have driven the emergence of novel vaccine
design approaches. In this regard, much effort has been put into the development
of new safe adjuvants and vaccine platforms. Of particular interest, the
utilization of plant virus-like nanoparticles and recombinant plant viruses has
gained increasing significance as an effective tool in the development of novel
vaccines against infectious diseases and cancer. The present review summarizes
recent advances in the use of plant viruses as nanoparticle-based vaccines and
adjuvants and their mechanism of action. Harnessing plant-virus immunogenic
properties will enable the design of novel, safe, and efficacious prophylactic
and therapeutic vaccines against disease.