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10.1152/ajpcell.00292.2015 http://scihub22266oqcxt.onion/10.1152/ajpcell.00292.2015 C4835917!4835917 !26825124     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26825124 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Cell+Physiol 2016 ; 310 (8 ): C625-8 Nephropedia Template TP {{tp|p=26825124 |t=2016. Pivotal role of AKAP121 in mitochondrial physiology |pdf=|usr=}}{{26825124 }} gab.com Text Pivotal role of AKAP121 in mitochondrial physiology JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26825124 #FOAvip In this Perspective, we discuss some recent developments in the study of the mitochondrial scaffolding protein AKAP121 (also known as AKAP1, or AKAP149 as the human homolog), with an emphasis on its role in mitochondrial physiology. AKAP121 has been identified to function as a key regulatory molecule in several mitochondrial events including oxidative phosphorylation, the control of membrane potential, fission-induced apoptosis, maintenance of mitochondrial Ca(2+)homeostasis, and the phosphorylation of various mitochondrial respiratory chain substrate molecules. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. Twit Text FOAVip Pivotal role of AKAP121 in mitochondrial physiology ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=26825124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26825124 #FOAvip English Wikipedia <ref>{{Cite pmid|26825124 }}</ref> Pivotal role of AKAP121 in mitochondrial physiology #MMPMID26825124 Czachor A ; Failla A ; Lockey R ; Kolliputi N Am J Physiol Cell Physiol 2016[Apr]; 310 (8 ): C625-8 PMID26825124 show ga In this Perspective, we discuss some recent developments in the study of the mitochondrial scaffolding protein AKAP121 (also known as AKAP1, or AKAP149 as the human homolog), with an emphasis on its role in mitochondrial physiology. AKAP121 has been identified to function as a key regulatory molecule in several mitochondrial events including oxidative phosphorylation, the control of membrane potential, fission-induced apoptosis, maintenance of mitochondrial Ca(2+)homeostasis, and the phosphorylation of various mitochondrial respiratory chain substrate molecules. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. |*Models, Biological [MESH] |A Kinase Anchor Proteins/*physiology [MESH] |Animals [MESH] |Apoptosis/*physiology [MESH] |Humans [MESH] |Membrane Potential, Mitochondrial/*physiology [MESH] |Mitochondria/*physiology [MESH] |Oxidation-Reduction [MESH] |Oxidative Stress/*physiology [MESH]Pivotal role of AKAP121 in mitochondrial physiology (epmc).pdf DeepDyve Pubget Overpricing