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10.1016/j.matbio.2015.01.023

http://scihub22266oqcxt.onion/10.1016/j.matbio.2015.01.023
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C4560244!4560244!25661523
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suck abstract from ncbi


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pmid25661523      Matrix+Biol 2015 ; 43 (ä): 15-26
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  • Pivotal Role for Decorin in Angiogenesis #MMPMID25661523
  • Järveläinen H; Sainio A; Wight TN
  • Matrix Biol 2015[Apr]; 43 (ä): 15-26 PMID25661523show ga
  • Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly collagenous and non-collagenous matrix constituents. In this review we have focused on the role and potential mechanisms of a multifunctional small leucine-rich proteoglycan decorin in angiogenesis. Depending on the cellular and molecular microenvironment where angiogenesis occurs, decorin can exhibit either a proangiogenic or an antiangiogenic activity. Nevertheless, in tumorigenesis-associated angiogenesis and in various inflammatory processes, particularly foreign body reactions and scarring, decorin exhibits an antiangiogenic activity, thus providing a potential basis for the development of decorin-based therapies in these pathological situations.
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