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10.1210/jc.2015-3653 http://scihub22266oqcxt.onion/10.1210/jc.2015-3653 C4803158!4803158 !26908107     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26908107 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Endocrinol+Metab 2016 ; 101 (3 ): 769-77 Nephropedia Template TP {{tp|p=26908107 |t=2016. Pituitary Medicine From Discovery to Patient-Focused Outcomes |pdf=|usr=}}{{26908107 }} gab.com Text Pituitary Medicine From Discovery to Patient-Focused Outcomes JO: J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26908107 #FOAvip CONTEXT: This perspective traces a pipeline of discovery in pituitary medicine over the past 75 years. OBJECTIVE: To place in context past advances and predict future changes in understanding pituitary pathophysiology and clinical care. DESIGN: Author's perspective on reports of pituitary advances in the published literature. SETTING: Clinical and translational Endocrinology. OUTCOMES: Discovery of the hypothalamic-pituitary axis and mechanisms for pituitary control, have culminated in exquisite understanding of anterior pituitary cell function and dysfunction. Challenges facing the discipline include fundamental understanding of pituitary adenoma pathogenesis leading to more effective treatments of inexorably growing and debilitating hormone secreting pituitary tumors as well as medical management of non-secreting pituitary adenomas. Newly emerging pituitary syndromes include those associated with immune-targeted cancer therapies and head trauma. CONCLUSIONS: Novel diagnostic techniques including imaging genomic, proteomic, and biochemical analyses will yield further knowledge to enable diagnosis of heretofore cryptic syndromes, as well as sub classifications of pituitary syndromes for personalized treatment approaches. Cost effective personalized approaches to precision therapy must demonstrate value, and will be empowered by multidisciplinary approaches to integrating complex subcellular information to identify therapeutic targets for enabling maximal outcomes. These goals will be challenging to attain given the rarity of pituitary disorders and the difficulty in conducting appropriately powered prospective trials. Twit Text FOAVip Pituitary Medicine From Discovery to Patient-Focused Outcomes ????J Clin Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=26908107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26908107 #FOAvip English Wikipedia <ref>{{Cite pmid|26908107 }}</ref> Pituitary Medicine From Discovery to Patient-Focused Outcomes #MMPMID26908107 Melmed S J Clin Endocrinol Metab 2016[Mar]; 101 (3 ): 769-77 PMID26908107 show ga CONTEXT: This perspective traces a pipeline of discovery in pituitary medicine over the past 75 years. OBJECTIVE: To place in context past advances and predict future changes in understanding pituitary pathophysiology and clinical care. DESIGN: Author's perspective on reports of pituitary advances in the published literature. SETTING: Clinical and translational Endocrinology. OUTCOMES: Discovery of the hypothalamic-pituitary axis and mechanisms for pituitary control, have culminated in exquisite understanding of anterior pituitary cell function and dysfunction. Challenges facing the discipline include fundamental understanding of pituitary adenoma pathogenesis leading to more effective treatments of inexorably growing and debilitating hormone secreting pituitary tumors as well as medical management of non-secreting pituitary adenomas. Newly emerging pituitary syndromes include those associated with immune-targeted cancer therapies and head trauma. CONCLUSIONS: Novel diagnostic techniques including imaging genomic, proteomic, and biochemical analyses will yield further knowledge to enable diagnosis of heretofore cryptic syndromes, as well as sub classifications of pituitary syndromes for personalized treatment approaches. Cost effective personalized approaches to precision therapy must demonstrate value, and will be empowered by multidisciplinary approaches to integrating complex subcellular information to identify therapeutic targets for enabling maximal outcomes. These goals will be challenging to attain given the rarity of pituitary disorders and the difficulty in conducting appropriately powered prospective trials. |Adrenocorticotropic Hormone/biosynthesis [MESH] |Human Growth Hormone/metabolism [MESH] |Humans [MESH] |Pituitary Neoplasms/etiology/metabolism/*therapy [MESH]Pituitary Medicine From Discovery to Patient-Focused Outcomes (epmc).pdf DeepDyve Pubget Overpricing