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10.18632/oncotarget.15534 http://scihub22266oqcxt.onion/10.18632/oncotarget.15534 C5421866!5421866 !28445938     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28445938 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28445938 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (15 ): 24506-24517 Nephropedia Template TP {{tp|p=28445938 |t=2017. Pirfenidone normalizes the tumor microenvironment to improve chemotherapy |pdf=|usr=}}{{28445938 }} gab.com Text Pirfenidone normalizes the tumor microenvironment to improve chemotherapy JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28445938 #FOAvip Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion and thus, improve drug delivery and the efficacy of cancer therapy. Therefore, we now need to identify safe and well tolerated pharmaceutical agents that are able to remodel the microenvironment of solid tumors and enhance chemotherapy. In this study, we repurposed Pirfenidone, a clinically approved anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis, to investigate its possible role on tumor microenvironment normalization. Using two orthotopic mammary tumor models we demonstrate that Pirfenidone reduces collagen and hyaluronan levels and, as a result, significantly increases blood vessel functionality and perfusion and improves the anti-tumor efficacy of doxorubicin. Reduction of extracellular matrix components were mediated via TGF? signaling pathway inhibition due to downregulation of TGF?1, COL1A1, COL3A1, HAS2, HAS3 expression levels. Our findings provide evidence that repurposing Pirfenidone could be used as a promising strategy to enhance drug delivery to solid tumors by normalizing the tumor microenvironment. Twit Text FOAVip Pirfenidone normalizes the tumor microenvironment to improve chemotherapy ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28445938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28445938 #FOAvip English Wikipedia <ref>{{Cite pmid|28445938 }}</ref> Pirfenidone normalizes the tumor microenvironment to improve chemotherapy #MMPMID28445938 Polydorou C ; Mpekris F ; Papageorgis P ; Voutouri C ; Stylianopoulos T Oncotarget 2017[Apr]; 8 (15 ): 24506-24517 PMID28445938 show ga Normalization of the tumor microenvironment by selectively targeting components of the tumor extracellular matrix has been recently proposed to have the potential to decompress tumor blood vessels, increase vessel perfusion and thus, improve drug delivery and the efficacy of cancer therapy. Therefore, we now need to identify safe and well tolerated pharmaceutical agents that are able to remodel the microenvironment of solid tumors and enhance chemotherapy. In this study, we repurposed Pirfenidone, a clinically approved anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis, to investigate its possible role on tumor microenvironment normalization. Using two orthotopic mammary tumor models we demonstrate that Pirfenidone reduces collagen and hyaluronan levels and, as a result, significantly increases blood vessel functionality and perfusion and improves the anti-tumor efficacy of doxorubicin. Reduction of extracellular matrix components were mediated via TGF? signaling pathway inhibition due to downregulation of TGF?1, COL1A1, COL3A1, HAS2, HAS3 expression levels. Our findings provide evidence that repurposing Pirfenidone could be used as a promising strategy to enhance drug delivery to solid tumors by normalizing the tumor microenvironment. |Antineoplastic Agents/pharmacology/*therapeutic use [MESH] |Drug Delivery Systems [MESH] |Humans [MESH] |Pyridones/pharmacology/*therapeutic use [MESH]Pirfenidone normalizes the tumor microenvironment to improve chemother(epmc).pdf DeepDyve Pubget Overpricing