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2014 ; 78
(3
): 418-37
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Picornavirus morphogenesis
#MMPMID25184560
Jiang P
; Liu Y
; Ma HC
; Paul AV
; Wimmer E
Microbiol Mol Biol Rev
2014[Sep]; 78
(3
): 418-37
PMID25184560
show ga
The Picornaviridae represent a large family of small plus-strand RNA viruses that
cause a bewildering array of important human and animal diseases. Morphogenesis
is the least-understood step in the life cycle of these viruses, and this process
is difficult to study because encapsidation is tightly coupled to genome
translation and RNA replication. Although the basic steps of assembly have been
known for some time, very few details are available about the mechanism and
factors that regulate this process. Most of the information available has been
derived from studies of enteroviruses, in particular poliovirus, where recent
evidence has shown that, surprisingly, the specificity of encapsidation is
governed by a viral protein-protein interaction that does not involve an RNA
packaging signal. In this review, we make an attempt to summarize what is
currently known about the following topics: (i) encapsidation intermediates, (ii)
the specificity of encapsidation (iii), viral and cellular factors that are
required for encapsidation, (iv) inhibitors of encapsidation, and (v) a model of
enterovirus encapsidation. Finally, we compare some features of picornavirus
morphogenesis with those of other plus-strand RNA viruses.
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