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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Rev+Endocrinol
2017 ; 13
(6
): 324-337
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Physiology and role of irisin in glucose homeostasis
#MMPMID28211512
Perakakis N
; Triantafyllou GA
; Fernández-Real JM
; Huh JY
; Park KH
; Seufert J
; Mantzoros CS
Nat Rev Endocrinol
2017[Jun]; 13
(6
): 324-337
PMID28211512
show ga
Irisin is a myokine that leads to increased energy expenditure by stimulating the
'browning' of white adipose tissue. In the first description of this hormone,
increased levels of circulating irisin, which is cleaved from its precursor
fibronectin type III domain-containing protein 5, were associated with improved
glucose homeostasis by reducing insulin resistance. Consequently, several studies
attempted to characterize the role of irisin in glucose regulation, but
contradictory results have been reported, and even the existence of this hormone
has been questioned. In this Review, we present the current knowledge on the
physiology of irisin and its role in glucose homeostasis. We describe the
mechanisms involved in the synthesis, secretion, circulation and regulation of
irisin, and the controversies regarding the measurement of irisin. We also
discuss the direct effects of irisin on glucose regulatory mechanisms in
different organs, the indirect effects and interactions with other hormones, and
the important open questions with regard to irisin in those organs. Finally, we
present the results from animal interventional studies and from human clinical
studies investigating the association of irisin with obesity, insulin resistance,
type 2 diabetes mellitus and the metabolic syndrome.
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