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2016 ; 3
(12
): 582-587
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Physiology, phylogeny, and LUCA
#MMPMID28357330
Martin WF
; Weiss MC
; Neukirchen S
; Nelson-Sathi S
; Sousa FL
Microb Cell
2016[Nov]; 3
(12
): 582-587
PMID28357330
show ga
Genomes record their own history. But if we want to look all the way back to
life's beginnings some 4 billion years ago, the record of microbial evolution
that is preserved in prokaryotic genomes is not easy to read. Microbiology has a
lot in common with geology in that regard. Geologists know that plate tectonics
and erosion have erased much of the geological record, with ancient rocks being
truly rare. The same is true of microbes. Lateral gene transfer (LGT) and
sequence divergence have erased much of the evolutionary record that was once
written in genomes, and it is not obvious which genes among sequenced genomes are
genuinely ancient. Which genes trace to the last universal ancestor, LUCA? The
classical approach has been to look for genes that are universally distributed.
Another approach is to make all trees for all genes, and sift out the trees where
signals have been overwritten by LGT. What is left ought to be ancient. If we do
that, what do we find?
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