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2017 ; 469
(3-4
): 365-374
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Physiological roles of macrophages
#MMPMID28185068
Gordon S
; Martinez-Pomares L
Pflugers Arch
2017[Apr]; 469
(3-4
): 365-374
PMID28185068
show ga
Macrophages are present in mammals from midgestation, contributing to physiologic
homeostasis throughout life. Macrophages arise from yolk sac and foetal liver
progenitors during embryonic development in the mouse and persist in different
organs as heterogeneous, self-renewing tissue-resident populations. Bone
marrow-derived blood monocytes are recruited after birth to replenish
tissue-resident populations and to meet further demands during inflammation,
infection and metabolic perturbations. Macrophages of mixed origin and different
locations vary in replication and turnover, but are all active in mRNA and
protein synthesis, fulfilling organ-specific and systemic trophic functions, in
addition to host defence. In this review, we emphasise selected properties and
non-immune functions of tissue macrophages which contribute to physiologic
homeostasis.