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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2007 ; 11
(4
): 685-703
Nephropedia Template TP
J Cell Mol Med
2007[Jul]; 11
(4
): 685-703
PMID17760833
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Physiological polyamines are ubiquitous polycations with pleiotropic biochemical
activities, including regulation of gene expression, cell proliferation and
modulation of cell signalling. Reports that the polyamines with cytoprotective
activities were induced by diverse stresses raised the hypothesis that
physiological polyamines may play a role in inducing stress response. In a wide
range of organisms, physiological polyamines were not only induced by diverse
stresses, such as reactive oxygen species (ROS), heat, ultraviolet (UV) and
psychiatric stress but were able to confer beneficial effects for survival.
Recent biochemical and genetic evidences show that polyamines can function as an
ROS scavenger, acid tolerance factor and chemical chaperone, and positive
regulators for expression of stress response genes which may explain their
protective functions against diverse stresses. Taken together, these data suggest
that physiological polyamines can function as primordial stress molecules in
bacteria, plants and mammals, and may play an essential role in regulation of
pathogen-host interactions.
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