Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/jci.insight.99453 http://scihub22266oqcxt.onion/10.1172/jci.insight.99453 C5922281!5922281 !29515039     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29515039 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2018 ; 3 (5 ): ä Nephropedia Template TP {{tp|p=29515039 |t=2018. Physiological mechanisms of sustained fumagillin-induced weight loss |pdf=|usr=}}{{29515039 }} gab.com Text Physiological mechanisms of sustained fumagillin-induced weight loss JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29515039 #FOAvip Current obesity interventions suffer from lack of durable effects and undesirable complications. Fumagillin, an inhibitor of methionine aminopeptidase-2, causes weight loss by reducing food intake, but with effects on weight that are superior to pair-feeding. Here, we show that feeding of rats on a high-fat diet supplemented with fumagillin (HF/FG) suppresses the aggressive feeding observed in pair-fed controls (HF/PF) and alters expression of circadian genes relative to the HF/PF group. Multiple indices of reduced energy expenditure are observed in HF/FG but not HF/PF rats. HF/FG rats also exhibit changes in gut hormones linked to food intake, increased energy harvest by gut microbiota, and caloric spilling in the urine. Studies in gnotobiotic mice reveal that effects of fumagillin on energy expenditure but not feeding behavior may be mediated by the gut microbiota. In sum, fumagillin engages weight loss-inducing behavioral and physiologic circuits distinct from those activated by simple caloric restriction. Twit Text FOAVip Physiological mechanisms of sustained fumagillin-induced weight loss ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29515039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29515039 #FOAvip English Wikipedia <ref>{{Cite pmid|29515039 }}</ref> Physiological mechanisms of sustained fumagillin-induced weight loss #MMPMID29515039 An J ; Wang L ; Patnode ML ; Ridaura VK ; Haldeman JM ; Stevens RD ; Ilkayeva O ; Bain JR ; Muehlbauer MJ ; Glynn EL ; Thomas S ; Muoio D ; Summers SA ; Vath JE ; Hughes TE ; Gordon JI ; Newgard CB JCI Insight 2018[Mar]; 3 (5 ): ä PMID29515039 show ga Current obesity interventions suffer from lack of durable effects and undesirable complications. Fumagillin, an inhibitor of methionine aminopeptidase-2, causes weight loss by reducing food intake, but with effects on weight that are superior to pair-feeding. Here, we show that feeding of rats on a high-fat diet supplemented with fumagillin (HF/FG) suppresses the aggressive feeding observed in pair-fed controls (HF/PF) and alters expression of circadian genes relative to the HF/PF group. Multiple indices of reduced energy expenditure are observed in HF/FG but not HF/PF rats. HF/FG rats also exhibit changes in gut hormones linked to food intake, increased energy harvest by gut microbiota, and caloric spilling in the urine. Studies in gnotobiotic mice reveal that effects of fumagillin on energy expenditure but not feeding behavior may be mediated by the gut microbiota. In sum, fumagillin engages weight loss-inducing behavioral and physiologic circuits distinct from those activated by simple caloric restriction. |Aminopeptidases/antagonists & inhibitors [MESH] |Animals [MESH] |Bacteria/drug effects/*isolation & purification/metabolism [MESH] |Behavior, Animal/drug effects [MESH] |Body Weight/drug effects [MESH] |Cyclohexanes/*administration & dosage [MESH] |Diet, High-Fat/adverse effects [MESH] |Disease Models, Animal [MESH] |Energy Metabolism/*drug effects [MESH] |Fatty Acids, Unsaturated/*administration & dosage [MESH] |Feces/microbiology [MESH] |Feeding Behavior/drug effects [MESH] |Gastrointestinal Microbiome/*drug effects/physiology [MESH] |Germ-Free Life/drug effects/physiology [MESH] |Glycoproteins/antagonists & inhibitors [MESH] |Humans [MESH] |Male [MESH] |Methionyl Aminopeptidases [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Obesity/*drug therapy/etiology/metabolism [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Sesquiterpenes/administration & dosage [MESH] |Treatment Outcome [MESH]Physiological mechanisms of sustained fumagillin-induced weight loss (epmc).pdf DeepDyve Pubget Overpricing