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2014 ; 33
(4
): 869-77
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Physiological functions of MTA family of proteins
#MMPMID25344801
Sen N
; Gui B
; Kumar R
Cancer Metastasis Rev
2014[Dec]; 33
(4
): 869-77
PMID25344801
show ga
Although the functional significance of the metastasic tumor antigen (MTA) family
of chromatin remodeling proteins in the pathobiology of cancer is fairly well
recognized, the physiological role of MTA proteins continues to be an
understudied research area and is just beginning to be recognized. Similar to
cancer cells, MTA1 also modulates the expression of target genes in normal cells
either by acting as a corepressor or coactivator. In addition, physiological
functions of MTA proteins are likely to be influenced by its differential
expression, subcellular localization, and regulation by upstream modulators and
extracellular signals. This review summarizes our current understanding of the
physiological functions of the MTA proteins in model systems. In particular, we
highlight recent advances of the role MTA proteins play in the brain, eye,
circadian rhythm, mammary gland biology, spermatogenesis, liver, immunomodulation
and inflammation, cellular radio-sensitivity, and hematopoiesis and
differentiation. Based on the growth of knowledge regarding the exciting new
facets of the MTA family of proteins in biology and medicine, we speculate that
the next burst of findings in this field may reveal further molecular regulatory
insights of non-redundant functions of MTA coregulators in the normal physiology
as well as in pathological conditions outside cancer.
|Animals
[MESH]
|Caenorhabditis elegans
[MESH]
|Chromatin Assembly and Disassembly/*genetics/physiology
[MESH]
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