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10.1007/s12035-014-8654-4 http://scihub22266oqcxt.onion/10.1007/s12035-014-8654-4 C4134430!4134430 !24532247     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24532247 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Neurobiol 2014 ; 50 (2 ): 339-47 Nephropedia Template TP {{tp|p=24532247 |t=2014. Physiological and pathological functions of mechanosensitive ion channels |pdf=|usr=}}{{24532247 }} gab.com Text Physiological and pathological functions of mechanosensitive ion channels JO: Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=24532247 #FOAvip Rapid sensation of mechanical stimuli is often mediated by mechanosensitve ion channels. Their opening results from conformational changes induced by mechanical forces. It leads to membrane permeation of selected ions and thereby to electrical signaling. Newly identified mechanosensitive ion channels are emerging at an astonishing rate, including some that are traditionally assigned for completely different functions. In this review, we first provide a brief overview of ion channels that are known to play a role in mechanosensation. Next, we focus on three representative ones, including the transient receptor potential channel V4 (TRPV4), Kv1.1 voltage-gated potassium (Kv) channel, and Piezo channels. Their structures, biophysical properties, expression and targeting patterns, and physiological functions are highlighted. The potential role of their mechanosensation in related diseases is further discussed. In sum, mechanosensation appears to be achieved in a variety of ways by different proteins and plays a fundamental role in the function of various organs under normal and abnormal conditions. Twit Text FOAVip Physiological and pathological functions of mechanosensitive ion channels ????Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=24532247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24532247 #FOAvip English Wikipedia <ref>{{Cite pmid|24532247 }}</ref> Physiological and pathological functions of mechanosensitive ion channels #MMPMID24532247 Gu Y ; Gu C Mol Neurobiol 2014[Oct]; 50 (2 ): 339-47 PMID24532247 show ga Rapid sensation of mechanical stimuli is often mediated by mechanosensitve ion channels. Their opening results from conformational changes induced by mechanical forces. It leads to membrane permeation of selected ions and thereby to electrical signaling. Newly identified mechanosensitive ion channels are emerging at an astonishing rate, including some that are traditionally assigned for completely different functions. In this review, we first provide a brief overview of ion channels that are known to play a role in mechanosensation. Next, we focus on three representative ones, including the transient receptor potential channel V4 (TRPV4), Kv1.1 voltage-gated potassium (Kv) channel, and Piezo channels. Their structures, biophysical properties, expression and targeting patterns, and physiological functions are highlighted. The potential role of their mechanosensation in related diseases is further discussed. In sum, mechanosensation appears to be achieved in a variety of ways by different proteins and plays a fundamental role in the function of various organs under normal and abnormal conditions. |Animals [MESH] |Cell Membrane Permeability/*physiology [MESH] |Humans [MESH] |Ion Channel Gating/*physiology [MESH] |Mechanoreceptors/*metabolism [MESH] |Membrane Proteins/*metabolism [MESH] |Potassium Channels/*metabolism [MESH]Physiological and pathological functions of mechanosensitive ion chann(epmc).pdf DeepDyve Pubget Overpricing