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10.1038/ncomms8292 http://scihub22266oqcxt.onion/10.1038/ncomms8292 C4490354!4490354 !26073653     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26073653 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 7292 Nephropedia Template TP {{tp|p=26073653 |t=2015. Physical principles of membrane remodelling during cell mechanoadaptation |pdf=|usr=}}{{26073653 }} gab.com Text Physical principles of membrane remodelling during cell mechanoadaptation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26073653 #FOAvip Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes. Twit Text FOAVip Physical principles of membrane remodelling during cell mechanoadaptation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26073653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26073653 #FOAvip English Wikipedia <ref>{{Cite pmid|26073653 }}</ref> Physical principles of membrane remodelling during cell mechanoadaptation #MMPMID26073653 Kosmalska AJ ; Casares L ; Elosegui-Artola A ; Thottacherry JJ ; Moreno-Vicente R ; González-Tarragó V ; Del Pozo MÁ ; Mayor S ; Arroyo M ; Navajas D ; Trepat X ; Gauthier NC ; Roca-Cusachs P Nat Commun 2015[Jun]; 6 (ä): 7292 PMID26073653 show ga Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes. |Adaptation, Physiological/*physiology [MESH] |Animals [MESH] |Cell Membrane/*physiology [MESH] |Cell Shape [MESH] |Cell Size [MESH] |Elasticity [MESH] |Fibroblasts/*physiology [MESH] |Mice [MESH] |Models, Biological [MESH] |Models, Theoretical [MESH] |Osmolar Concentration [MESH]Physical principles of membrane remodelling during cell mechanoadaptat(epmc).pdf DeepDyve Pubget Overpricing