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Phylogenetic analysis of otospiralin protein
#MMPMID27099854
Torktaz I
; Behjati M
; Rostami A
Adv Biomed Res
2016[]; 5
(?): 41
PMID27099854
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BACKGROUND: Fibrocyte-specific protein, otospiralin, is a small protein, widely
expressed in the central nervous system as neuronal cell bodies and glia. The
increased expression of otospiralin in reactive astrocytes implicates its role in
signaling pathways and reparative mechanisms subsequent to injury. Indeed,
otospiralin is considered to be essential for the survival of fibrocytes of the
mesenchymal nonsensory regions of the cochlea. It seems that other functions of
this protein are not yet completely understood. MATERIALS AND METHODS: Amino acid
sequences of otospiralin from 12 vertebrates were derived from National Center
for Biotechnology Information database. Phylogenetic analysis and phylogeny
estimation were performed using MEGA 5.0.5 program, and neighbor-joining tree was
constructed by this software. RESULTS: In this computational study, the
phylogenetic tree of otospiralin has been investigated. Therefore, dendrograms of
otospiralin were depicted. Alignment performed in MUSCLE method by UPGMB
algorithm. Also, entropy plot determined for a better illustration of amino acid
variations in this protein. CONCLUSION: In the present study, we used otospiralin
sequence of 12 different species and by constructing phylogenetic tree, we
suggested out group for some related species.
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