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2015 ; 21
(5
): 476-82
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Photovoltaic restoration of sight with high visual acuity
#MMPMID25915832
Lorach H
; Goetz G
; Smith R
; Lei X
; Mandel Y
; Kamins T
; Mathieson K
; Huie P
; Harris J
; Sher A
; Palanker D
Nat Med
2015[May]; 21
(5
): 476-82
PMID25915832
show ga
Patients with retinal degeneration lose sight due to the gradual demise of
photoreceptors. Electrical stimulation of surviving retinal neurons provides an
alternative route for the delivery of visual information. We demonstrate that
subretinal implants with 70-?m-wide photovoltaic pixels provide highly localized
stimulation of retinal neurons in rats. The electrical receptive fields recorded
in retinal ganglion cells were similar in size to the natural visual receptive
fields. Similarly to normal vision, the retinal response to prosthetic
stimulation exhibited flicker fusion at high frequencies, adaptation to static
images and nonlinear spatial summation. In rats with retinal degeneration, these
photovoltaic arrays elicited retinal responses with a spatial resolution of 64 ±
11 ?m, corresponding to half of the normal visual acuity in healthy rats. The
ease of implantation of these wireless and modular arrays, combined with their
high resolution, opens the door to the functional restoration of sight in
patients blinded by retinal degeneration.
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