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10.3390/ijms160920523 http://scihub22266oqcxt.onion/10.3390/ijms160920523 C4613217!4613217 !26334268     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26334268 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (9 ): 20523-59 Nephropedia Template TP {{tp|p=26334268 |t=2015. Photodynamic Efficiency: From Molecular Photochemistry to Cell Death |pdf=|usr=}}{{26334268 }} gab.com Text Photodynamic Efficiency: From Molecular Photochemistry to Cell Death JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26334268 #FOAvip Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious diseases. The main agent is the photosensitizer (PS), which is excited by light and converted to a triplet excited state. This latter species leads to the formation of singlet oxygen and radicals that oxidize biomolecules. The main motivation for this review is to suggest alternatives for achieving high-efficiency PDT protocols, by taking advantage of knowledge on the chemical and biological processes taking place during and after photosensitization. We defend that in order to obtain specific mechanisms of cell death and maximize PDT efficiency, PSes should oxidize specific molecular targets. We consider the role of subcellular localization, how PS photochemistry and photophysics can change according to its nanoenvironment, and how can all these trigger specific cell death mechanisms. We propose that in order to develop PSes that will cause a breakthrough enhancement in the efficiency of PDT, researchers should first consider tissue and intracellular localization, instead of trying to maximize singlet oxygen quantum yields in in vitro tests. In addition to this, we also indicate many open questions and challenges remaining in this field, hoping to encourage future research. Twit Text FOAVip Photodynamic Efficiency: From Molecular Photochemistry to Cell Death ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26334268 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26334268 #FOAvip English Wikipedia <ref>{{Cite pmid|26334268 }}</ref> Photodynamic Efficiency: From Molecular Photochemistry to Cell Death #MMPMID26334268 Bacellar IO ; Tsubone TM ; Pavani C ; Baptista MS Int J Mol Sci 2015[Aug]; 16 (9 ): 20523-59 PMID26334268 show ga Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious diseases. The main agent is the photosensitizer (PS), which is excited by light and converted to a triplet excited state. This latter species leads to the formation of singlet oxygen and radicals that oxidize biomolecules. The main motivation for this review is to suggest alternatives for achieving high-efficiency PDT protocols, by taking advantage of knowledge on the chemical and biological processes taking place during and after photosensitization. We defend that in order to obtain specific mechanisms of cell death and maximize PDT efficiency, PSes should oxidize specific molecular targets. We consider the role of subcellular localization, how PS photochemistry and photophysics can change according to its nanoenvironment, and how can all these trigger specific cell death mechanisms. We propose that in order to develop PSes that will cause a breakthrough enhancement in the efficiency of PDT, researchers should first consider tissue and intracellular localization, instead of trying to maximize singlet oxygen quantum yields in in vitro tests. In addition to this, we also indicate many open questions and challenges remaining in this field, hoping to encourage future research. |*Photochemistry [MESH] |*Photochemotherapy/methods [MESH] |Animals [MESH] |Cell Death/drug effects/radiation effects [MESH] |Humans [MESH] |Oxidation-Reduction/drug effects/radiation effects [MESH]Photodynamic Efficiency: From Molecular Photochemistry to Cell Death (epmc).pdf DeepDyve Pubget Overpricing