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2015 ; 1851
(6
): 844-56
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Phosphoinositides regulate ion channels
#MMPMID25241941
Hille B
; Dickson EJ
; Kruse M
; Vivas O
; Suh BC
Biochim Biophys Acta
2015[Jun]; 1851
(6
): 844-56
PMID25241941
show ga
Phosphoinositides serve as signature motifs for different cellular membranes and
often are required for the function of membrane proteins. Here, we summarize
clear evidence supporting the concept that many ion channels are regulated by
membrane phosphoinositides. We describe tools used to test their dependence on
phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider
mechanisms and biological meanings of phosphoinositide regulation of ion
channels. This lipid regulation can underlie changes of channel activity and
electrical excitability in response to receptors. Since different intracellular
membranes have different lipid compositions, the activity of ion channels still
in transit towards their final destination membrane may be suppressed until they
reach an optimal lipid environment. This article is part of a Special Issue
entitled Phosphoinositides.
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