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2014 ; 223
(ä): 1143-76
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Phosphoinositide regulation of TRP channels
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Rohacs T
Handb Exp Pharmacol
2014[]; 223
(ä): 1143-76
PMID24961984
show ga
Transient Receptor Potential (TRP) channels are activated by stimuli as diverse
as heat, cold, noxious chemicals, mechanical forces, hormones, neurotransmitters,
spices, and voltage. Besides their presumably similar general architecture,
probably the only common factor regulating them is phosphoinositides. The
regulation of TRP channels by phosphoinositides is complex. There are a large
number of TRP channels where phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2 or
PIP2] acts as a positive cofactor, similarly to many other ion channels. In
several cases, however, PI(4,5)P2 inhibits TRP channel activity, sometimes even
concurrently with the activating effect. This chapter will provide a
comprehensive overview of the literature on regulation of TRP channels by
membrane phosphoinositides.