Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23640492
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arterioscler+Thromb+Vasc+Biol
2013 ; 33
(6
): 1120-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Phenotypic polarization of macrophages in atherosclerosis
#MMPMID23640492
Leitinger N
; Schulman IG
Arterioscler Thromb Vasc Biol
2013[Jun]; 33
(6
): 1120-6
PMID23640492
show ga
Macrophages orchestrate the inflammatory response in inflamed tissues, and recent
work indicates that these cells can alter their phenotypes and functions
accordingly in response to changes in the microenvironment. Initial work in
models of cardiovascular disease used immunologic markers to characterize
macrophage phenotypes present in atherosclerotic plaque, and these studies have
lately been extended through the use of markers that are more specific for
atherosclerosis and metabolic disease. Together, these studies have led to a
novel view of the function of macrophages in the development of atherosclerosis
that suggests dynamic plasticity. Understanding this plasticity and the ensuing
macrophage heterogeneity could lead to novel strategies of pharmacological
intervention to combat chronic inflammation in metabolic diseases. Most
importantly, revealing the functional characteristics of individual macrophage
phenotypes will lead to a better understanding of their contribution to lesion
development and plaque stability.
free
free
free
