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2014 ; 121
(ä): 31-42
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Pharmacology of serotonin and female sexual behavior
#MMPMID24239784
Uphouse L
Pharmacol Biochem Behav
2014[Jun]; 121
(ä): 31-42
PMID24239784
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In this review, first a historical perspective of serotonin's (5-HT) involvement
in female sexual behavior is presented. Then an overview of studies implicating
5-HT is presented. The effect of drugs that increase or decrease CNS levels of
5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have
negative effects on female sexual behavior while a decrease in 5-HT is associated
with facilitation of sexual behavior. Studies with compounds that act on 5-HT?,
5-HT? or 5-HT? receptors are discussed. Most evidence indicates that 5-HT?A
receptor agonists inhibit sexual behavior while 5-HT? or 5-HT? receptors may
exert a positive influence. There is substantial evidence to support a role for
5-HT in the modulation of female consummatory sexual behavior, but studies on the
role of 5-HT in other elements of female sexual behavior (e.g. desire,
motivation, sexual appetite) are few. Future studies should be directed at
determining if these additional components of female sexual behavior are also
modulated by 5-HT.
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