Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24798681
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 ACS+Chem+Neurosci
2014 ; 5
(6
): 468-76
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pharmacological and toxicological effects of lithium in zebrafish
#MMPMID24798681
Siebel AM
; Vianna MR
; Bonan CD
ACS Chem Neurosci
2014[Jun]; 5
(6
): 468-76
PMID24798681
show ga
Lithium is the paradigmatic treatment for bipolar disorder and has been widely
used as a mood stabilizer due to its ability to reduce manic and depressive
episodes, efficiency in long-term mood stabilization, and effectiveness in
reducing suicide risks. Despite many decades of clinical use, the molecular
targets of lithium are not completely understood. However, they are credited at
least partially to glycogen synthase kinase 3 (GSK3) inhibition, mimicking and
exacerbating Wnt signaling pathway activation. There has been a great effort to
characterize lithium cellular and system actions, aiming to improve treatment
effectiveness and reduce side effects. There is also a growing concern about
lithium's impact as an environmental contaminant and its effects on development.
In this scenario, zebrafish is a helpful model organism to gather more
information on lithium's effects in different systems and developmental stages.
The rapid external development, initial transparency, capacity to easily absorb
substances, and little space required for maintenance and experimentation, among
other advantages, make zebrafish a suitable model. In addition, zebrafish has
been established as an effective model organism in behavioral and
neuropharmacological studies, reacting to a wide range of psychoactive drugs,
including lithium. So far only a limited number of studies evaluated the
toxicological impact of lithium on zebrafish development and demonstrated
morphological, physiological, and behavioral effects that may be informative
regarding human findings. Further studies dedicated to characterize and evaluate
the underlying mechanisms of the toxic effects and the potential impact of
exposure on developing and adult individuals are necessary to establish safe
clinical management guidelines for women with bipolar disorder of childbearing
age and safety disposal guidelines for pharmaceutical neuroactive compounds.
free
free
free
