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10.1007/s00068-015-0613-x http://scihub22266oqcxt.onion/10.1007/s00068-015-0613-x C4886148!4886148 !26660675     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26660675 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+J+Trauma+Emerg+Surg 2016 ; 42 (3 ): 303-10 Nephropedia Template TP {{tp|p=26660675 |t=2016. Pharmacological adjuncts to stop bleeding: options and effectiveness |pdf=|usr=}}{{26660675 }} gab.com Text Pharmacological adjuncts to stop bleeding: options and effectiveness JO: Eur J Trauma Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=26660675 #FOAvip Severe trauma and massive haemorrhage represent the leading cause of death and disability in patients under the age of 45 years in the developed world. Even though much advancement has been made in our understanding of the pathophysiology and management of trauma, outcomes from massive haemorrhage remain poor. This can be partially explained by the development of coagulopathy, acidosis and hypothermia, a pathological process collectively known as the "lethal triad" of trauma. A number of pharmacological adjuncts have been utilised to stop bleeding, with a wide variation in the safety and efficacy profiles. Antifibrinolytic agents in particular, act by inhibiting the conversion of plasminogen to plasmin, therefore decreasing the degree of fibrinolysis. Tranexamic acid, the most commonly used antifibrinolytic agent, has been successfully incorporated into most trauma management protocols effectively reducing mortality and morbidity following trauma. In this review, we discuss the current literature with regard to the management of haemorrhage following trauma, with a special reference to the use of pharmacological adjuncts. Novel insights, concepts and treatment modalities are also discussed. Twit Text FOAVip Pharmacological adjuncts to stop bleeding: options and effectiveness ????Eur J Trauma Emerg Surg http://www.kidney.de/pget.php?&tw=1&pmid=26660675 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26660675 #FOAvip English Wikipedia <ref>{{Cite pmid|26660675 }}</ref> Pharmacological adjuncts to stop bleeding: options and effectiveness #MMPMID26660675 Panteli M ; Pountos I ; Giannoudis PV Eur J Trauma Emerg Surg 2016[Jun]; 42 (3 ): 303-10 PMID26660675 show ga Severe trauma and massive haemorrhage represent the leading cause of death and disability in patients under the age of 45 years in the developed world. Even though much advancement has been made in our understanding of the pathophysiology and management of trauma, outcomes from massive haemorrhage remain poor. This can be partially explained by the development of coagulopathy, acidosis and hypothermia, a pathological process collectively known as the "lethal triad" of trauma. A number of pharmacological adjuncts have been utilised to stop bleeding, with a wide variation in the safety and efficacy profiles. Antifibrinolytic agents in particular, act by inhibiting the conversion of plasminogen to plasmin, therefore decreasing the degree of fibrinolysis. Tranexamic acid, the most commonly used antifibrinolytic agent, has been successfully incorporated into most trauma management protocols effectively reducing mortality and morbidity following trauma. In this review, we discuss the current literature with regard to the management of haemorrhage following trauma, with a special reference to the use of pharmacological adjuncts. Novel insights, concepts and treatment modalities are also discussed. |Acidosis/etiology/*therapy [MESH] |Antifibrinolytic Agents/*therapeutic use [MESH] |Blood Coagulation Disorders/etiology/*therapy [MESH] |Blood Coagulation Tests [MESH] |Blood Transfusion/*methods [MESH] |Clinical Protocols [MESH] |Fibrinolysis [MESH] |Hemorrhage/etiology/*therapy [MESH] |Humans [MESH] |Hypothermia/etiology/*therapy [MESH] |Multiple Trauma/complications/physiopathology/*therapy [MESH]Pharmacological adjuncts to stop bleeding: options and effectiveness (epmc).pdf DeepDyve Pubget Overpricing