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10.1038/s41598-017-10336-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-10336-8 C5572703!5572703 !28842716     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28842716 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 9503 Nephropedia Template TP {{tp|p=28842716 |t=2017. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury |pdf=|usr=}}{{28842716 }} gab.com Text Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842716 #FOAvip Renal ischemia/reperfusion is a major cause of acute kidney injury. However, the pathogenic mechanisms underlying renal ischemia/reperfusion injury (IRI) are not fully defined. Here, we investigated the role of PTEN, a dual protein/lipid phosphatase, in the development of ischemic AKI in mice. Pharmacological inhibition of PTEN with bpV(HOpic) exacerbated renal dysfunction and promoted tubular damage in mice with IRI compared with vehicle-treated mice with IRI. PTEN inhibition enhanced tubular cell apoptosis in kidneys with IRI, which was associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expanded the infiltration of neutrophils and macrophages into kidneys with IRI, which was accompanied by increased expression of the proinflammatory molecules. These results have demonstrated that PTEN plays a crucial role in the pathogenesis of ischemic acute kidney injury through regulating tubular cell apoptosis and inflammation suggesting PTEN could be a potential therapeutic target for acute kidney injury. Twit Text FOAVip Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28842716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28842716 #FOAvip English Wikipedia <ref>{{Cite pmid|28842716 }}</ref> Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury #MMPMID28842716 Zhou J ; Jia L ; Hu Z ; Wang Y Sci Rep 2017[Aug]; 7 (1 ): 9503 PMID28842716 show ga Renal ischemia/reperfusion is a major cause of acute kidney injury. However, the pathogenic mechanisms underlying renal ischemia/reperfusion injury (IRI) are not fully defined. Here, we investigated the role of PTEN, a dual protein/lipid phosphatase, in the development of ischemic AKI in mice. Pharmacological inhibition of PTEN with bpV(HOpic) exacerbated renal dysfunction and promoted tubular damage in mice with IRI compared with vehicle-treated mice with IRI. PTEN inhibition enhanced tubular cell apoptosis in kidneys with IRI, which was associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expanded the infiltration of neutrophils and macrophages into kidneys with IRI, which was accompanied by increased expression of the proinflammatory molecules. These results have demonstrated that PTEN plays a crucial role in the pathogenesis of ischemic acute kidney injury through regulating tubular cell apoptosis and inflammation suggesting PTEN could be a potential therapeutic target for acute kidney injury. |*Protein Aggregation, Pathological/complications/metabolism [MESH] |Acute Kidney Injury/drug therapy/*etiology/*metabolism/physiopathology [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Biomarkers [MESH] |Cytokines/metabolism [MESH] |Enzyme Activation [MESH] |Enzyme Inhibitors/*pharmacology [MESH] |Immunohistochemistry [MESH] |Inflammation Mediators/metabolism [MESH] |Ischemia/complications/metabolism [MESH] |Male [MESH] |Mice [MESH] |PTEN Phosphohydrolase/*antagonists & inhibitors/*metabolism [MESH] |Protein Aggregates/*drug effects [MESH]Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury (epmc).pdf DeepDyve Pubget Overpricing