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2015 ; 13
(5
): 592-604
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Pharmacological Approaches for Treatment-resistant Bipolar Disorder
#MMPMID26467409
Hui Poon S
; Sim K
; Baldessarini RJ
Curr Neuropharmacol
2015[]; 13
(5
): 592-604
PMID26467409
show ga
Bipolar disorder is prevalent, with high risks of disability, substance abuse and
premature mortality. Treatment responses typically are incomplete, especially for
depressive components, so that many cases can be considered "treatment
resistant." We reviewed reports on experimental treatments for such patients:
there is a striking paucity of such research, mainly involving small incompletely
controlled trials of add-on treatment, and findings remain preliminary.
Encouraging results have been reported by adding aripiprazole, bupropion,
clozapine, ketamine, memantine, pramipexole, pregabalin, and perhaps
tri-iodothyronine in resistant manic or depressive phases. The urgency of
incomplete responses in such a severe illness underscores the need for more
systematic, simpler, and better controlled studies in more homogeneous samples of
patients.
|Animals
[MESH]
|Antidepressive Agents/adverse effects/*therapeutic use
[MESH]
|Bipolar Disorder/*drug therapy
[MESH]
|Databases, Bibliographic/statistics & numerical data
[MESH]