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10.1016/j.addr.2015.12.004 http://scihub22266oqcxt.onion/10.1016/j.addr.2015.12.004 C4902794!4902794 !26686832     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26686832 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2016 ; 104 (ä): 93-109 Nephropedia Template TP {{tp|p=26686832 |t=2016. Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines |pdf=|usr=}}{{26686832 }} gab.com Text Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=26686832 #FOAvip Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad therapeutic potentials toward various diseases including viral infections and cancer. With recent advances in bioconjugate chemistry and carrier technology, several siRNA-based drugs have advanced to clinical trials. However, most cases address local applications or diseases in the filtering organs, reflecting remaining challenges in systemic delivery of siRNA. The difficulty in siRNA delivery is in large part due to poor circulation stability and unfavorable pharmacokinetics and biodistribution profiles of siRNA. This review describes the pharmacokinetics and biodistribution of siRNA nanomedicines, focusing on those reported in the past 5years, and their pharmacological effects in selected disease models such as hepatocellular carcinoma, liver infections, and respiratory diseases. The examples discussed here will provide an insight into the current status of the art and unmet needs in siRNA delivery. Twit Text FOAVip Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=26686832 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26686832 #FOAvip English Wikipedia <ref>{{Cite pmid|26686832 }}</ref> Pharmacokinetics and biodistribution of recently-developed siRNA nanomedicines #MMPMID26686832 Park J ; Park J ; Pei Y ; Xu J ; Yeo Y Adv Drug Deliv Rev 2016[Sep]; 104 (ä): 93-109 PMID26686832 show ga Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad therapeutic potentials toward various diseases including viral infections and cancer. With recent advances in bioconjugate chemistry and carrier technology, several siRNA-based drugs have advanced to clinical trials. However, most cases address local applications or diseases in the filtering organs, reflecting remaining challenges in systemic delivery of siRNA. The difficulty in siRNA delivery is in large part due to poor circulation stability and unfavorable pharmacokinetics and biodistribution profiles of siRNA. This review describes the pharmacokinetics and biodistribution of siRNA nanomedicines, focusing on those reported in the past 5years, and their pharmacological effects in selected disease models such as hepatocellular carcinoma, liver infections, and respiratory diseases. The examples discussed here will provide an insight into the current status of the art and unmet needs in siRNA delivery. |*Nanomedicine [MESH] |*RNA, Small Interfering/pharmacokinetics/therapeutic use [MESH] |*RNAi Therapeutics [MESH] |Animals [MESH] |Carcinoma, Hepatocellular/genetics/metabolism/*therapy [MESH] |Humans [MESH] |Liver Neoplasms/genetics/metabolism/*therapy [MESH] |RNA Interference [MESH] |Respiratory Tract Diseases/genetics/metabolism/therapy [MESH]Pharmacokinetics and biodistribution of recently-developed siRNA nanom(epmc).pdf DeepDyve Pubget Overpricing