Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26336972
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Drugs+Aging
2015 ; 32
(9
): 717-26
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pharmaceutical Management of Trigeminal Neuralgia in the Elderly
#MMPMID26336972
Oomens MA
; Forouzanfar T
Drugs Aging
2015[Sep]; 32
(9
): 717-26
PMID26336972
show ga
Classical trigeminal neuralgia (CTN) is a severe neuropathic pain in the
distribution of one or more branches of the trigeminal nerve, which occurs in
recurrent episodes, causing deterioration in quality of life, affecting everyday
habits and inducing severe disability. The aim of this review is to give an
overview of the current literature on pharmaceutical treatment options for CTN in
the elderly. The first-line treatment for the management of CTN in adults is an
antiepileptic-carbamazepine or oxcarbazepine. There is a lack of research on the
use of antiepileptics in the elderly. This is a deficiency, as the use of
antiepileptics raises a number of problems due to the polypharmacotherapy common
in older patients. This can induce drug interactions due to co-morbidities and
changes in pharmacokinetics and pharmacodynamics. Furthermore, the side effects
of carbamazepine include central nervous system disturbances, such as a lack of
balance, dizziness, somnolence, renal dysfunction and cardiac arrhythmias, which
are poorly tolerated by the elderly. Unfortunately, the efficacy and safety of
alternative treatment options have not been systematically evaluated. On the
basis of the current literature, it is not possible to give an evidence-based
recommendation for first-line pharmaceutical management of CTN specifically for
the elderly.
|*Quality of Life
[MESH]
|Aged
[MESH]
|Anticonvulsants/*therapeutic use
[MESH]
|Carbamazepine/analogs & derivatives/therapeutic use
[MESH]