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2017 ; 2017
(ä): 9042851
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Phagocytosis: A Fundamental Process in Immunity
#MMPMID28691037
Rosales C
; Uribe-Querol E
Biomed Res Int
2017[]; 2017
(ä): 9042851
PMID28691037
show ga
One hundred years have passed since the death of Élie Metchnikoff (1845-1916). He
was the first to observe the uptake of particles by cells and realized the
importance of this process for the host response to injury and infection. He also
was a strong advocate of the role of phagocytosis in cellular immunity, and with
this he gave us the basis for our modern understanding of inflammation and the
innate and acquired immune responses. Phagocytosis is an elegant but complex
process for the ingestion and elimination of pathogens, but it is also important
for the elimination of apoptotic cells and hence fundamental for tissue
homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of
the target particle, (ii) signaling to activate the internalization machinery,
(iii) phagosome formation, and (iv) phagolysosome maturation. In recent years,
the use of new tools of molecular biology and microscopy has provided new
insights into the cellular mechanisms of phagocytosis. In this review, we present
a general view of our current knowledge on phagocytosis. We emphasize novel
molecular findings, particularly on phagosome formation and maturation, and
discuss aspects that remain incompletely understood.
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