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2014 ; 5
(4
): e944039
Nephropedia Template TP
gab.com Text
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English Wikipedia
Pervasive transcription: detecting functional RNAs in bacteria
#MMPMID25483405
Lybecker M
; Bilusic I
; Raghavan R
Transcription
2014[]; 5
(4
): e944039
PMID25483405
show ga
Pervasive, or genome-wide, transcription has been reported in all domains of
life. In bacteria, most pervasive transcription occurs antisense to
protein-coding transcripts, although recently a new class of pervasive RNAs was
identified that originates from within annotated genes. Initially considered to
be non-functional transcriptional noise, pervasive transcription is increasingly
being recognized as important in regulating gene expression. The function of
pervasive transcription is an extensively debated question in the field of
transcriptomics and regulatory RNA biology. Here, we highlight the most recent
contributions addressing the purpose of pervasive transcription in bacteria and
discuss their implications.