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Permeability factors in focal and segmental glomerulosclerosis
#MMPMID25168830
Reiser J
; Nast CC
; Alachkar N
Adv Chronic Kidney Dis
2014[Sep]; 21
(5
): 417-21
PMID25168830
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Focal and segmental glomerulosclerosis (FSGS) represents a group of glomerular
disorders, identified on kidney biopsy, that progress in the histopathologic
pattern of sclerosis in parts of some glomeruli. Damage to podocytes usually
marks the beginning of the disease, most evident in primary FSGS. In addition to
genetic predisposition, there are many acquired causes that disturb normal
podocyte homeostasis and allow for the development of FSGS. The aim of this
review was to summarize recent findings of the most relevant circulating
permeability factors that may serve as biomarkers of active primary idiopathic
FSGS and aid in the diagnosis and prediction of recurrent FSGS after kidney
transplantation.
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