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10.1038/nmeth.3147 http://scihub22266oqcxt.onion/10.1038/nmeth.3147 C4245323!4245323 !25344638     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25344638 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Methods 2014 ; 11 (12 ): 1261-6 Nephropedia Template TP {{tp|p=25344638 |t=2014. Permanent genetic memory with 1-byte capacity |pdf=|usr=}}{{25344638 }} gab.com Text Permanent genetic memory with 1-byte capacity JO: Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=25344638 #FOAvip Genetic memory enables the recording of information in the DNA of living cells. Memory can record a transient environmental signal or cell state that is then recalled at a later time. Permanent memory is implemented using irreversible recombinases that invert the orientation of a unit of DNA, corresponding to the [0,1] state of a bit. To expand the memory capacity, we have applied bioinformatics to identify 34 phage integrases (and their cognate attB and attP recognition sites), from which we build 11 memory switches that are perfectly orthogonal to each other and the FimE and HbiF bacterial invertases. Using these switches, a memory array is constructed in Escherichia coli that can record 1.375 bytes of information. It is demonstrated that the recombinases can be layered and used to permanently record the transient state of a transcriptional logic gate. Twit Text FOAVip Permanent genetic memory with 1-byte capacity ????Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=25344638 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25344638 #FOAvip English Wikipedia <ref>{{Cite pmid|25344638 }}</ref> Permanent genetic memory with 1-byte capacity #MMPMID25344638 Yang L ; Nielsen AA ; Fernandez-Rodriguez J ; McClune CJ ; Laub MT ; Lu TK ; Voigt CA Nat Methods 2014[Dec]; 11 (12 ): 1261-6 PMID25344638 show ga Genetic memory enables the recording of information in the DNA of living cells. Memory can record a transient environmental signal or cell state that is then recalled at a later time. Permanent memory is implemented using irreversible recombinases that invert the orientation of a unit of DNA, corresponding to the [0,1] state of a bit. To expand the memory capacity, we have applied bioinformatics to identify 34 phage integrases (and their cognate attB and attP recognition sites), from which we build 11 memory switches that are perfectly orthogonal to each other and the FimE and HbiF bacterial invertases. Using these switches, a memory array is constructed in Escherichia coli that can record 1.375 bytes of information. It is demonstrated that the recombinases can be layered and used to permanently record the transient state of a transcriptional logic gate. |*Gene Expression Regulation, Bacterial [MESH] |Bacteriophages/enzymology/*genetics [MESH] |Computational Biology [MESH] |DNA, Bacterial/*genetics [MESH] |DNA-Binding Proteins/genetics/metabolism [MESH] |Escherichia coli Proteins/*genetics [MESH] |Escherichia coli/genetics/growth & development [MESH] |Integrases/*genetics [MESH] |Memory/*physiology [MESH] |Recombinases/*genetics/metabolism [MESH]Permanent genetic memory with 1-byte capacity (epmc).pdf DeepDyve Pubget Overpricing