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2014 ; 29
(5
): 314-24
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Peripheral and central glucose sensing in hypoglycemic detection
#MMPMID25180261
Donovan CM
; Watts AG
Physiology (Bethesda)
2014[Sep]; 29
(5
): 314-24
PMID25180261
show ga
Hypoglycemia poses a serious threat to the integrity of the brain, owing to its
reliance on blood glucose as a fuel. Protecting against hypoglycemia is an
extended network of glucose sensors located within the brain and in the periphery
that serve to mediate responses restoring euglycemia, i.e., counterregulatory
responses. This review examines the various glucose sensory loci involved in
hypoglycemic detection, with a particular emphasis on peripheral glucose sensory
loci and their contribution to hypoglycemic counterregulation.